Born in Calgary. She attended the Alberta College of Art and Design.
She has received numerous awards for her work on Saga published by Image Comics. These include Harvey Awards in 2013, 2014, 2015 & 2016 for Best Artist, in 2013 for Best Colourist and in 2014, 2015 & 2016 for Best Cover Artist. She won Eisner Awards in 2014 for Best Painter/Multimedia Artist (interior art)) and in 2017 for Best Penciller/Inker and for Best Cover Artist.
She has received Joe Shuster Awards in 2011 for Outstanding Comic Book Cover Artist and in 2014 for Best Artist, and received Ringo Awards in 2017 for Best Artist or Penciller and in 2019 for Best Cover Artist. In addition she has won multiple awards in partnership in Brain K. Vaughan.
Captain Canuck, 4, Sept. 2015: Cover C:
Canadian Review Of Comparative Literature, 43-1, March 2016: “Fiona Staples and the Long Horizon.” Writ., Matilda Roche: 180-193.